Product Name : L-asparaginase
Other Names: L-Asparaginase; ASP; L-ASP; Elspar; Asparaginase
CAS number : 9015-68-3
Molecular Formula: C4H7NO4
Appearance/Color : White powder
Applications: It is used for leukopenia, thrombocytopenia and aplastic anemia caused by various reasons

How L-Asparaginase Works

L-Asparaginase works by depleting the levels of L-asparagine in the bloodstream. L-asparagine is necessary for the growth and survival of leukemia cells. By depriving cancer cells of this amino acid, L-asparaginase effectively starves them, inhibiting their ability to proliferate and survive.

Medical Applications

1. Treatment of Acute Lymphoblastic Leukemia (ALL): L-Asparaginase is a cornerstone in the treatment protocol for ALL, especially in pediatric patients. It is often used in combination with other chemotherapy agents to achieve better therapeutic outcomes.
2. Other Cancers: Besides ALL, L-Asparaginase has shown potential in the treatment of other malignancies, such as non-Hodgkin lymphoma and acute myeloid leukemia, although its use in these cancers is less common.

Types of L-Asparaginase

There are two main types of L-Asparaginase used in clinical practice:

• E. coli-derived L-Asparaginase: This type is derived from the bacterium Escherichia coli and was one of the earliest forms used in cancer treatment.
• Erwinia-derived L-Asparaginase: This form is derived from the bacterium Erwinia chrysanthemi. It is often used when patients develop hypersensitivity or allergic reactions to the E. coli-derived version.

Challenges and Side Effects

While L-Asparaginase is highly effective, it does pose certain challenges:

• Immunogenicity: Some patients develop antibodies against L-Asparaginase, reducing its effectiveness over time.
• Side Effects: Common side effects include nausea, vomiting, pancreatitis, and allergic reactions. Close monitoring and supportive care are essential during treatment.